DLC1

Across TCGA patient cohorts, DLC1 mutation is significantly associated with the total protein of many other genes, with 77 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DLC1-associated genes across cancer lineages are ASNS, Caspase-7-cleavedD198, and 4E-BP1. Each is linked with DLC1 in more than 5 cancer types. Because this analysis shows association rather than direction, both DLC1-to-partner and partner-to-DLC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASNS grouped by DLC1-low versus DLC1-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DLC1→partner) and Y-score (partner→DLC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	ASNS →	+0.504	+3.807	<.001	<.001	3	5
COAD	Caspase-7-cleavedD198 →	+0.905	+1.686	<.001	.013	3	5
LUAD	4E-BP1 →	+0.487	+3.000	.002	.036	1	6
COAD	14-3-3_epsilon →	+0.124	+1.900	.005	.028	3	4
COAD	Rad50 →	-0.279	-1.669	<.001	.022	3	4
BRCA	Bcl-2 →	-0.571	-3.169	.032	.020	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 77 associations by consensus.

ASNS by DLC1 expression — STAD

Explore this box plot interactively →