DLC1

Across TCGA cell cohorts, DLC1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,821 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible DLC1-associated GO terms across cancer lineages are Regulation of cell-matrix adhesion, Regulation of focal adhesion assembly, and Regulation of cell-substrate junction assembly. Each is linked with DLC1 in more than 12 cancer types. Because this analysis shows association rather than direction, both DLC1-to-partner and partner-to-DLC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of cell-matrix adhesion grouped by DLC1-low versus DLC1-high in CNS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (DLC1→partner) and Y-score (partner→DLC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	Regulation of cell-matrix adhesion →	+0.089	+1.827	<.001	<.001	3	13
BONE	Regulation of focal adhesion assembly →	+0.151	+2.026	<.001	<.001	3	12
BONE	Regulation of cell-substrate junction assembly →	+0.151	+2.026	<.001	<.001	3	12
BONE	Regulation of cellular response to growth factor stimulus →	+0.065	+1.396	<.001	.003	2	13
BONE	Regulation of cell-substrate junction organization →	+0.126	+1.846	<.001	<.001	3	12
LUNG_NSCLC_LUSC	Positive regulation of cell-substrate junction organization →	+0.162	+3.092	<.001	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,821 associations by consensus.

Regulation of cell-matrix adhesion by DLC1 expression — CNS

Explore this box plot interactively →