DLC1

Across TCGA cell cohorts, DLC1 mutation is significantly associated with the RNA expression of many other genes, with 2,245 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible DLC1-associated genes across cancer lineages are SLCO1C1, FZD3, and ZNF330. Each is linked with DLC1 in more than 1 cancer types. Because this analysis shows association rather than direction, both DLC1-to-partner and partner-to-DLC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SLCO1C1 grouped by DLC1-low versus DLC1-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DLC1→partner) and Y-score (partner→DLC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	SLCO1C1 →	+0.192	+3.750	<.001	.003	3	2
LARGE_INTESTINE	FZD3 →	+0.628	+1.891	.001	<.001	3	2
LARGE_INTESTINE	ZNF330 →	+0.424	+1.891	.001	<.001	3	2
LARGE_INTESTINE	SEPSECS →	+0.654	+1.891	<.001	<.001	3	2
LARGE_INTESTINE	OSBPL9 →	+0.478	+2.700	<.001	.001	3	2
LARGE_INTESTINE	CASP8AP2 →	+0.548	+2.286	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,245 associations by consensus.

SLCO1C1 by DLC1 expression — LUNG_SCLC

Explore this box plot interactively →