DLAT

Across TCGA pan-cancer cohorts, DLAT mass-spec protein differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of DLAT’s most consistent transcriptional readouts.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where DLAT mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types DLAT is over-expressed in tumor, although a few such as CCRCC and HNSC show the opposite, repressed pattern.

CCRCC, HNSC, and COAD are the cancer types where DLAT tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in DLAT mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
CCRCC	Male	IV	−0.780	<.001	12	view →
HNSC	All	II,III,IV	−1.000	<.001	11	view →
COAD	All	II,III,IV	−0.134	<.001	10	view →
LSCC	Male	All	−0.122	.001	6	view →
LUAD	All	All	+0.115	.004	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

DLAT–CCRCC

Open the CCRCC breakdown →