DLAT

Across TCGA patient cohorts, DLAT mutation is significantly associated with the total protein of many other genes, with 9 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DLAT-associated genes across cancer lineages are ASNS, eIF4E, and A-Raf_pS299. Each is linked with DLAT in more than 1 cancer types. Because this analysis shows association rather than direction, both DLAT-to-partner and partner-to-DLAT results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASNS grouped by DLAT-low versus DLAT-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DLAT→partner) and Y-score (partner→DLAT) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ASNS →	+0.610	+2.000	<.001	.032	3	2
UCEC	eIF4E →	+0.235	+2.700	.013	.006	3	1
UCEC	A-Raf_pS299 →	-0.120	-2.000	.026	.032	3	1
UCEC	MEK1 →	+0.463	+2.459	.004	.019	3	1
UCEC	p62 Lck ligand →	+0.462	+3.179	.001	.010	3	1
UCEC	STAT3_pY705 →	-0.336	-2.311	.004	.034	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

ASNS by DLAT expression — UCEC

Explore this box plot interactively →