Across TCGA pan-cancer cohorts, DKKL1P1 RNA differs between tumor and matched normal tissue in 2 of 18 cancer types tested, making tumor–normal expression one of DKKL1P1’s most consistent transcriptional readouts.
The strongest signal is observed in stomach adenocarcinoma (STAD), where DKKL1P1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types DKKL1P1 is over-expressed in tumor, although a few such as ESCA show the opposite, repressed pattern.
STAD and ESCA are the cancer types where DKKL1P1 tumor–normal differential expression is most reproducible.