DKKL1

Across TCGA pan-cancer cohorts, DKKL1 Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated DKKL1 data layer compared with 20 for mass-spec protein.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher DKKL1 Mutation is associated with better overall survival. In most high-consensus cancer types, elevated DKKL1 expression acts as an unfavorable survival marker, although some lineages such as LUAD show a favorable association.

LUAD, SARC, and LIHC are the cancer types where DKKL1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Median	III,IV	0.508	0.321	.005	9	view →
SARC	DFS	Median	All	0.121	0.611	.041	6	view →
LIHC	DFS	Median	All	0.096	0.543	.028	6	view →
BLCA	OS	Median	All	0.216	0.618	.049	3	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

DKKL1–LUAD (OS)

Open the LUAD breakdown →