DKK3

Across TCGA patient cohorts, DKK3 RNA expression is significantly associated with the protein abundance of many other proteins, with 19,781 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible DKK3-associated proteins across cancer lineages are PDLIM7, FLNA, and ACTN1. Each is linked with DKK3 in more than 8 cancer types. Because this analysis shows association rather than direction, both DKK3-to-partner and partner-to-DKK3 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, DKK3 versus PDLIM7 in COAD, with a Pearson correlation of 0.36.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (DKK3→partner) and Y-score (partner→DKK3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	PDLIM7 →	+0.677	+0.707	<.001	<.001	3	9
UCEC	FLNA →	+0.631	+0.844	<.001	<.001	3	9
OV	ACTN1 →	+0.598	+1.415	<.001	<.001	3	9
PDAC	IGFBP7 →	+0.691	+0.607	<.001	<.001	3	9
UCEC	SVIL →	+0.650	+0.895	<.001	<.001	3	8
UCEC	SYNPO →	+0.525	+0.935	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 19,781 associations by consensus.

DKK3 vs PDLIM7 — COAD

Explore this scatter interactively →