DKK3

Across TCGA patient cohorts, DKK3 mutation is significantly associated with the RNA expression of many other genes, with 2,330 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DKK3-associated genes across cancer lineages are BNIP3P4, EML2-AS1, and DNAJA1P1. Each is linked with DKK3 in more than 1 cancer types. Because this analysis shows association rather than direction, both DKK3-to-partner and partner-to-DKK3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, BNIP3P4 grouped by DKK3-low versus DKK3-high in LIHC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DKK3→partner) and Y-score (partner→DKK3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIHC	BNIP3P4 →	+0.075	+5.479	<.001	.002	3	2
UCEC	EML2-AS1 →	+0.059	+1.914	.002	.004	3	2
CESC	DNAJA1P1 →	+0.036	+5.306	<.001	.006	3	2
BLCA	RPSAP65 →	+0.165	+3.629	<.001	.002	3	2
BLCA	FAM224B →	+0.163	+3.619	.005	.008	3	2
BRCA	IGHD5-24 →	+1.128	+5.070	<.001	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,330 associations by consensus.

BNIP3P4 by DKK3 expression — LIHC

Explore this box plot interactively →