DKK3

Across TCGA patient cohorts, DKK3 mutation is significantly associated with the total protein of many other genes, with 29 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DKK3-associated genes across cancer lineages are Bax, Cyclin-B1, and Src. Each is linked with DKK3 in more than 1 cancer types. Because this analysis shows association rather than direction, both DKK3-to-partner and partner-to-DKK3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Bax grouped by DKK3-low versus DKK3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DKK3→partner) and Y-score (partner→DKK3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Bax →	+0.238	+2.115	.023	.019	3	2
UCEC	Cyclin-B1 →	+0.822	+2.807	<.001	.003	3	2
SKCM	Src →	-0.282	-3.000	.032	.036	3	1
UCEC	eEF2 →	+0.317	+2.115	.042	.019	3	1
UCEC	EGFR_pY1068 →	-0.285	-2.807	.009	.003	3	1
UCEC	FOXO3a_pS318_S321 →	-0.154	-3.312	.004	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 29 associations by consensus.

Bax by DKK3 expression — UCEC

Explore this box plot interactively →