DKK3

Across TCGA cell cohorts, DKK3 RNA expression is significantly associated with the RNA expression of many other genes, with 10,719 significant associations in total. BONE shows the largest number of these associations.

The most reproducible DKK3-associated genes across cancer lineages are MYLK, SERPINE1, and COL12A1. Each is linked with DKK3 in more than 12 cancer types. Because this analysis shows association rather than direction, both DKK3-to-partner and partner-to-DKK3 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, DKK3 versus MYLK in BONE, with a Pearson correlation of 0.70.

RNA expression associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DKK3→partner) and Y-score (partner→DKK3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	MYLK →	+2.530	+4.070	<.001	<.001	3	13
BONE	SERPINE1 →	+4.835	+4.215	<.001	<.001	3	12
BONE	COL12A1 →	+5.291	+4.992	<.001	<.001	3	12
BONE	LOXL2 →	+3.727	+4.239	<.001	<.001	3	12
LUNG_NSCLC_LUSC	MMP2 →	+4.187	+4.164	.001	<.001	3	12
BONE	THBS1 →	+5.773	+4.476	<.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 10,719 associations by consensus.

DKK3 vs MYLK — BONE

Explore this scatter interactively →