DKK3

Across TCGA cell cohorts, DKK3 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,639 significant associations in total. BONE shows the largest number of these associations.

The most reproducible DKK3-associated GO terms across cancer lineages are Negative regulation of cortisol biosynthetic process, Negative regulation of glucocorticoid biosynthetic process, and Negative regulation of aldosterone biosynthetic process. Each is linked with DKK3 in more than 14 cancer types. Because this analysis shows association rather than direction, both DKK3-to-partner and partner-to-DKK3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of cortisol biosynthetic process grouped by DKK3-low versus DKK3-high in LIVER.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (DKK3→partner) and Y-score (partner→DKK3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	Negative regulation of cortisol biosynthetic process →	+1.282	+4.163	.003	<.001	3	15
LIVER	Negative regulation of glucocorticoid biosynthetic process →	+1.282	+4.163	.003	<.001	3	15
LIVER	Negative regulation of aldosterone biosynthetic process →	+1.282	+4.163	.003	<.001	3	15
LUNG_NSCLC_LUSC	Negative regulation of hormone biosynthetic process →	+1.403	+5.590	<.001	<.001	3	15
LIVER	Negative regulation of steroid hormone biosynthetic process →	+1.282	+4.163	.003	<.001	3	15
BONE	Dentinogenesis →	+1.863	+4.215	<.001	<.001	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,639 associations by consensus.

Negative regulation of cortisol biosynthetic process by DKK3 expression — LIVER

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