DKK3

Across TCGA cell cohorts, DKK3 mutation is significantly associated with the RNA expression of many other genes, with 17 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible DKK3-associated genes across cancer lineages are MAGEB5, MYOT, and SLC35G3. Each is linked with DKK3 in more than 1 cancer types. Because this analysis shows association rather than direction, both DKK3-to-partner and partner-to-DKK3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MAGEB5 grouped by DKK3-low versus DKK3-high in LUNG_NSCLC_LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DKK3→partner) and Y-score (partner→DKK3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	MAGEB5 →	+0.033	+4.643	<.001	.008	3	1
LARGE_INTESTINE	MYOT →	+0.099	+3.716	.002	.003	3	1
LARGE_INTESTINE	SLC35G3 →	+0.007	+3.297	<.001	.002	3	1
LARGE_INTESTINE	TBC1D21 →	+0.008	+3.700	<.001	.009	3	1
LARGE_INTESTINE	WDR87 →	+0.020	+3.353	<.001	.004	3	1
LARGE_INTESTINE	OR4F4 →	+0.015	+3.103	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

MAGEB5 by DKK3 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →