DKK2

Across TCGA patient cohorts, DKK2 RNA expression is significantly associated with the protein abundance of many other proteins, with 15,087 significant associations in total. BRCA shows the largest number of these associations.

The most reproducible DKK2-associated proteins across cancer lineages are PDLIM7, CAVIN3, and TLN1. Each is linked with DKK2 in more than 8 cancer types. Because this analysis shows association rather than direction, both DKK2-to-partner and partner-to-DKK2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, DKK2 versus PDLIM7 in UCEC, with a Pearson correlation of 0.43.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (DKK2→partner) and Y-score (partner→DKK2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PDLIM7 →	+0.995	+0.899	<.001	<.001	3	9
OV	CAVIN3 →	+0.813	+1.108	<.001	<.001	3	9
UCEC	TLN1 →	+0.460	+0.710	.001	.008	3	8
UCEC	MYLK →	+1.114	+0.949	<.001	<.001	3	8
UCEC	ILK →	+0.687	+0.864	<.001	.001	3	8
OV	COPZ2 →	+0.700	+0.800	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 15,087 associations by consensus.

DKK2 vs PDLIM7 — UCEC

Explore this scatter interactively →