DKK2

Across TCGA patient cohorts, DKK2 protein abundance is significantly associated with the RNA expression of many other genes, with 3,501 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible DKK2-associated genes across cancer lineages are DYSF, ADPRH, and SLC8A3. Each is linked with DKK2 in more than 1 cancer types. Because this analysis shows association rather than direction, both DKK2-to-partner and partner-to-DKK2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, DKK2 versus DYSF in BRCA, with a Pearson correlation of 0.47.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DKK2→partner) and Y-score (partner→DKK2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	DYSF →	+0.759	+0.801	.004	.007	3	2
BRCA	ADPRH →	+0.587	+0.876	.005	.009	3	2
LUAD	SLC8A3 →	+0.337	+0.880	.001	<.001	3	2
LUAD	PPP1R16B →	+0.831	+0.871	<.001	<.001	3	2
LSCC	CHRDL1 →	+1.363	+0.709	<.001	<.001	3	2
LUAD	CD40LG →	+0.738	+0.734	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,501 associations by consensus.

DKK2 vs DYSF — BRCA

Explore this scatter interactively →