DKK2

Across TCGA patient cohorts, DKK2 mutation is significantly associated with the total protein of many other genes, with 40 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DKK2-associated genes across cancer lineages are PCNA, Shc_pY317, and 4E-BP1. Each is linked with DKK2 in more than 3 cancer types. Because this analysis shows association rather than direction, both DKK2-to-partner and partner-to-DKK2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by DKK2-low versus DKK2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DKK2→partner) and Y-score (partner→DKK2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PCNA →	+0.221	+1.807	.002	.004	3	4
COAD	Shc_pY317 →	-0.257	-2.983	.001	.034	3	3
UCEC	4E-BP1 →	+0.363	+3.807	<.001	<.001	3	2
COAD	EGFR_pY1068 →	-0.413	-2.987	.007	.035	3	2
COAD	PRDX1 →	+0.154	+3.347	.031	.005	3	2
UCEC	ATM →	-0.543	-1.906	<.001	.015	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 40 associations by consensus.

PCNA by DKK2 expression — UCEC

Explore this box plot interactively →