DKK2

Across TCGA cell cohorts, DKK2 mutation is significantly associated with the RNA expression of many other genes, with 13 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible DKK2-associated genes across cancer lineages are SPIC, PRKAG3, and LRCH2. Each is linked with DKK2 in more than 1 cancer types. Because this analysis shows association rather than direction, both DKK2-to-partner and partner-to-DKK2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SPIC grouped by DKK2-low versus DKK2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DKK2→partner) and Y-score (partner→DKK2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	SPIC →	+0.293	+4.095	<.001	.009	3	2
BLOOD_Leukemia	PRKAG3 →	+0.035	+3.551	<.001	.009	3	1
BLOOD_Leukemia	LRCH2 →	+0.581	+3.807	<.001	.007	3	1
BLOOD_Leukemia	MMP20 →	+0.048	+3.705	<.001	.007	3	1
BLOOD_Leukemia	DEFB4A →	+0.125	+4.269	<.001	.002	3	1
BLOOD_Leukemia	TRIM49B →	+0.113	+5.289	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

SPIC by DKK2 expression — LARGE_INTESTINE

Explore this box plot interactively →