DKK1

Across TCGA pan-cancer cohorts, DKK1 Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated DKK1 data layer compared with 25 for mass-spec protein and 3 for mass-spec protein.

The strongest signal is observed in small cell lung cancer (SCLC), where higher DKK1 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated DKK1 expression acts as an unfavorable survival marker, although some lineages such as STAD and UCEC show a favorable association.

SCLC, STAD, and UCEC are the cancer types where DKK1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SCLC	OS	Median	All	0.082	0.708	<.001	12	view →
STAD	DFS	Median	All	1.000	0.381	.023	6	view →
UCEC	DFS	Median	All	0.961	0.627	.027	4	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

DKK1–SCLC (OS)

Open the SCLC breakdown →