DKK1

Across TCGA pan-cancer cohorts, DKK1 mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated DKK1 data layer compared with 25 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher DKK1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated DKK1 expression acts as an unfavorable survival marker.

PDAC, LUAD, and HNSC are the cancer types where DKK1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Quartile	II,III,IV	0.551	1.000	<.001	64	view →
LUAD	OS	Median	All	0.397	0.858	.049	2	view →
HNSC	OS	Tertile	All	0.492	1.000	.040	1	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

DKK1–PDAC (DFS)

Open the PDAC breakdown →