DKK1

Across TCGA patient cohorts, DKK1 RNA expression is significantly associated with the protein abundance of many other proteins, with 14,865 significant associations in total. GBM shows the largest number of these associations.

The most reproducible DKK1-associated proteins across cancer lineages are HMGA2, UACA, and SLK. Each is linked with DKK1 in more than 4 cancer types. Because this analysis shows association rather than direction, both DKK1-to-partner and partner-to-DKK1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, DKK1 versus HMGA2 in LUAD, with a Pearson correlation of 0.39.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (DKK1→partner) and Y-score (partner→DKK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	HMGA2 →	+1.393	+1.492	<.001	<.001	3	5
LUAD	UACA →	+0.261	+1.273	<.001	<.001	3	4
GBM	SLK →	+0.231	+1.435	.003	.008	3	4
GBM	DIAPH2 →	+0.450	+2.038	<.001	<.001	3	4
UCEC	FRMD6_S544 →	+0.614	+2.454	.004	<.001	3	4
BRCA	FSCN1 →	+0.550	+1.729	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 14,865 associations by consensus.

DKK1 vs HMGA2 — LUAD

Explore this scatter interactively →