DKK1

protein abundance — cross-omics
Cross-omicsPROTEIN-MS → RNAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, DKK1 protein abundance is significantly associated with the RNA expression of many other genes, with 3,210 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DKK1-associated genes across cancer lineages are PHLDB2, PROX1, and REM2. Each is linked with DKK1 in more than 2 cancer types. Because this analysis shows association rather than direction, both DKK1-to-partner and partner-to-DKK1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, DKK1 versus PHLDB2 in UCEC, with a Pearson correlation of 0.55.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DKK1→partner) and Y-score (partner→DKK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
UCECPHLDB2 →+1.265+2.597.001<.00133
UCECPROX1 →+4.039+3.417<.001<.00132
UCECREM2 →-1.195-1.812<.001.00132
UCECDDIT4L →+2.066+2.458<.001<.00132
UCECPLK2 →+1.155+2.077.003.00132
UCECDLGAP1-AS1 →+1.361+2.216.007.00132
Each partner links to its Q-omics profile. Showing the 6 strongest of 3,210 associations by consensus.

DKK1 vs PHLDB2 — UCEC

Per-sample scatter of DKK1 vs PHLDB2 in UCEC (Pearson r = 0.55).

Explore this scatter interactively →

Exploration