DKK1

Across TCGA patient cohorts, DKK1 mutation is significantly associated with the RNA expression of many other genes, with 3,197 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DKK1-associated genes across cancer lineages are RN7SL371P, RN7SL634P, and RNU6-650P. Each is linked with DKK1 in more than 2 cancer types. Because this analysis shows association rather than direction, both DKK1-to-partner and partner-to-DKK1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SL371P grouped by DKK1-low versus DKK1-high in LUSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DKK1→partner) and Y-score (partner→DKK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	RN7SL371P →	+0.105	+4.792	<.001	.006	3	3
BLCA	RN7SL634P →	+0.288	+4.017	<.001	.004	3	2
COAD	RNU6-650P →	+0.364	+4.392	<.001	.006	3	2
COAD	PRR23A →	+0.135	+4.547	<.001	.005	3	2
COAD	TRAJ21 →	+1.188	+3.408	<.001	.009	3	2
COAD	TANK-AS1 →	+0.465	+3.686	<.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,197 associations by consensus.

RN7SL371P by DKK1 expression — LUSC

Explore this box plot interactively →