DKK1

Across TCGA patient cohorts, DKK1 mutation is significantly associated with the total protein of many other genes, with 22 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DKK1-associated genes across cancer lineages are PCNA, Src_pY527, and Caspase-7-cleavedD198. Each is linked with DKK1 in more than 1 cancer types. Because this analysis shows association rather than direction, both DKK1-to-partner and partner-to-DKK1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PCNA grouped by DKK1-low versus DKK1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DKK1→partner) and Y-score (partner→DKK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PCNA →	+0.253	+1.415	.001	.046	3	2
UCEC	Src_pY527 →	-0.366	-2.105	.023	.017	3	2
UCEC	Caspase-7-cleavedD198 →	+0.655	+2.135	.003	.010	3	2
UCEC	4E-BP1 →	+0.298	+3.459	.003	.005	3	2
UCEC	EGFR_pY1068 →	-0.229	-2.169	.015	.003	3	1
UCEC	ERK2 →	+0.215	+2.000	.002	.030	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

PCNA by DKK1 expression — UCEC

Explore this box plot interactively →