DKK1

Across TCGA cell cohorts, DKK1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,509 significant associations in total. BONE shows the largest number of these associations.

The most reproducible DKK1-associated GO terms across cancer lineages are Motor learning, Regulation of midbrain dopaminergic neuron differentiation, and Regulation of mesodermal cell fate specification. Each is linked with DKK1 in more than 19 cancer types. Because this analysis shows association rather than direction, both DKK1-to-partner and partner-to-DKK1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Motor learning grouped by DKK1-low versus DKK1-high in OVARY.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (DKK1→partner) and Y-score (partner→DKK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	Motor learning →	+2.314	+5.517	<.001	<.001	3	20
STOMACH	Regulation of midbrain dopaminergic neuron differentiation →	+2.296	+5.702	<.001	<.001	3	20
STOMACH	Regulation of mesodermal cell fate specification →	+2.145	+5.584	<.001	<.001	3	19
STOMACH	Regulation of mesodermal cell differentiation →	+1.933	+5.434	<.001	<.001	3	17
STOMACH	Negative regulation of cell fate specification →	+1.578	+4.941	<.001	<.001	3	16
OVARY	Regulation of dopaminergic neuron differentiation →	+0.480	+3.546	<.001	<.001	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,509 associations by consensus.

Motor learning by DKK1 expression — OVARY

Explore this box plot interactively →