DKC1

Across TCGA patient cohorts, DKC1 mutation is significantly associated with the total protein of many other genes, with 25 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DKC1-associated genes across cancer lineages are ATM, eIF4E, and Caspase-7-cleavedD198. Each is linked with DKC1 in more than 2 cancer types. Because this analysis shows association rather than direction, both DKC1-to-partner and partner-to-DKC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by DKC1-low versus DKC1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DKC1→partner) and Y-score (partner→DKC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.561	-2.502	<.001	.001	3	3
UCEC	eIF4E →	+0.176	+1.874	.012	.002	3	2
UCEC	Caspase-7-cleavedD198 →	+0.607	+1.697	.002	.012	3	2
UCEC	c-Kit →	-0.222	-2.201	.004	<.001	3	2
UCEC	INPP4B →	-0.221	-2.000	.041	.029	3	1
UCEC	JNK_pT183_Y185 →	-0.151	-2.000	.007	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

ATM by DKC1 expression — UCEC

Explore this box plot interactively →