DIXDC1

Across TCGA pan-cancer cohorts, DIXDC1 mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated DIXDC1 data layer compared with 22 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher DIXDC1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated DIXDC1 expression acts as an unfavorable survival marker.

LUAD, PDAC, and LSCC are the cancer types where DIXDC1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Median	II,III,IV	0.744	0.936	<.001	22	view →
PDAC	DFS	Median	IV	0.231	0.934	.024	7	view →
LSCC	OS	Median	II,III,IV	0.824	1.000	.009	6	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

DIXDC1–LUAD (DFS)

Open the LUAD breakdown →