DIXDC1

Across TCGA patient cohorts, DIXDC1 mutation is significantly associated with the RNA expression of many other genes, with 4,430 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DIXDC1-associated genes across cancer lineages are RNU4-82P, SNORA84, and RNA5SP422. Each is linked with DIXDC1 in more than 1 cancer types. Because this analysis shows association rather than direction, both DIXDC1-to-partner and partner-to-DIXDC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU4-82P grouped by DIXDC1-low versus DIXDC1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DIXDC1→partner) and Y-score (partner→DIXDC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNU4-82P →	+0.279	+1.420	.001	.003	3	2
UCEC	SNORA84 →	+0.380	+1.674	.009	.001	3	2
UCEC	RNA5SP422 →	+0.670	+1.469	<.001	.007	3	2
UCEC	EIF4EBP1P1 →	+0.191	+1.693	.006	.001	3	2
BRCA	RAC1P6 →	+0.113	+7.234	<.001	<.001	3	2
SKCM	MIR6865 →	+0.729	+3.599	.003	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,430 associations by consensus.

RNU4-82P by DIXDC1 expression — UCEC

Explore this box plot interactively →