DIXDC1

Across TCGA cell cohorts, DIXDC1 mutation is significantly associated with the RNA expression of many other genes, with 5 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible DIXDC1-associated genes across cancer lineages are FTHL17, CLEC4D, and OR10AG1. Each is linked with DIXDC1 in more than 1 cancer types. Because this analysis shows association rather than direction, both DIXDC1-to-partner and partner-to-DIXDC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FTHL17 grouped by DIXDC1-low versus DIXDC1-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DIXDC1→partner) and Y-score (partner→DIXDC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	FTHL17 →	+2.187	+3.544	<.001	.009	3	1
LUNG_NSCLC_LUAD	CLEC4D →	+0.084	+4.093	<.001	.004	3	1
LUNG_NSCLC_LUAD	OR10AG1 →	+0.025	+4.078	<.001	.009	3	1
LUNG_NSCLC_LUAD	NKX2-6 →	+1.007	+3.544	<.001	.009	3	1
LUNG_NSCLC_LUAD	ZNF99 →	+0.318	+3.977	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

FTHL17 by DIXDC1 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →