Across TCGA patient cohorts, DISP3 mutation is significantly associated with the total protein of many other genes, with 93 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DISP3-associated genes across cancer lineages are p62 Lck ligand, 4E-BP1_pT37_T46, and Src_pY527. Each is linked with DISP3 in more than 3 cancer types. Because this analysis shows association rather than direction, both DISP3-to-partner and partner-to-DISP3 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DISP3→partner) and Y-score (partner→DISP3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p62 Lck ligand →	+0.405	+1.874	<.001	<.001	3	4
UCEC	4E-BP1_pT37_T46 →	-0.331	-1.501	.001	.012	3	4
COAD	Src_pY527 →	-0.368	-3.894	.004	<.001	3	4
STAD	c-Kit →	-0.294	-2.584	.026	.010	3	3
LUAD	MSH6 →	+0.245	+2.025	.018	.016	3	3
LUAD	TFRC →	+0.390	+3.000	.034	.034	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 93 associations by consensus.

Exploration

DISP3 survival (RNA) · tumor vs normal (RNA) · all DISP3 data types