DISP2

Across TCGA pan-cancer cohorts, DISP2 Mutation is linked to patient survival in 7 of 34 cancer types, making it a survival-associated DISP2 data layer compared with 22 for mass-spec protein and 2 for mass-spec protein.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where higher DISP2 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated DISP2 expression acts as an unfavorable survival marker, although some lineages such as UCEC and SKCM show a favorable association.

LUSC, UCEC, and LIHC are the cancer types where DISP2 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUSC	OS	Median	All	0.301	0.681	<.001	36	view →
UCEC	OS	Median	All	0.965	0.659	.039	12	view →
LIHC	DFS	Median	All	0.135	0.546	<.001	12	view →
TGCT	DFS	Median	All	0.106	0.807	<.001	6	view →
LGG	DFS	Median	All	0.068	0.826	<.001	3	view →
LUAD	OS	Median	All	0.373	0.687	.036	3	view →
SKCM	DFS	Median	All	0.959	0.711	.008	2	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

DISP2–LUSC (OS)

Open the LUSC breakdown →