DISP2

Across TCGA patient cohorts, DISP2 mutation is significantly associated with the total protein of many other genes, with 30 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DISP2-associated genes across cancer lineages are Caspase-7-cleavedD198, eEF2, and 4E-BP1. Each is linked with DISP2 in more than 2 cancer types. Because this analysis shows association rather than direction, both DISP2-to-partner and partner-to-DISP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by DISP2-low versus DISP2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DISP2→partner) and Y-score (partner→DISP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.467	+1.720	.023	.025	3	3
UCEC	eEF2 →	+0.257	+1.700	.038	.042	3	2
UCEC	4E-BP1 →	+0.284	+2.252	.002	.005	2	3
UCEC	Cyclin-B1 →	+0.445	+2.459	.022	.019	3	2
COAD	Gab2 →	-0.479	-2.974	.004	.036	3	2
COAD	MSH6 →	-0.644	-2.974	.001	.036	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 30 associations by consensus.

Caspase-7-cleavedD198 by DISP2 expression — UCEC

Explore this box plot interactively →