DISP1

Across TCGA cell cohorts, DISP1 mutation is significantly associated with the RNA expression of many other genes, with 900 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible DISP1-associated genes across cancer lineages are SEPHS1, ZAN, and TAS2R9. Each is linked with DISP1 in more than 2 cancer types. Because this analysis shows association rather than direction, both DISP1-to-partner and partner-to-DISP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SEPHS1 grouped by DISP1-low versus DISP1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DISP1→partner) and Y-score (partner→DISP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	SEPHS1 →	+0.479	+3.321	.003	.002	3	3
SOFT_TISSUE	ZAN →	+0.004	+4.369	<.001	.008	3	2
BLOOD_Leukemia	TAS2R9 →	+0.029	+2.908	<.001	.001	3	2
BLOOD_Leukemia	CLDN2 →	+0.116	+3.688	<.001	.001	3	2
BLOOD_Leukemia	ETV5 →	+1.353	+3.214	.002	.006	3	2
LARGE_INTESTINE	STIM2 →	+0.678	+1.977	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 900 associations by consensus.

SEPHS1 by DISP1 expression — LARGE_INTESTINE

Explore this box plot interactively →