DISC1

Across TCGA pan-cancer cohorts, DISC1 Mutation is linked to patient survival in 6 of 34 cancer types, making it a survival-associated DISC1 data layer compared with 21 for mass-spec protein and 6 for mass-spec protein.

The strongest signal is observed in ovarian serous cystadenocarcinoma (OV), where higher DISC1 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated DISC1 expression acts as an unfavorable survival marker, although some lineages such as UCEC and SCLC show a favorable association.

OV, UCEC, and PRAD are the cancer types where DISC1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
OV	OS	Median	All	0.295	0.843	<.001	36	view →
UCEC	DFS	Median	All	0.943	0.615	.005	18	view →
PRAD	DFS	Median	All	0.085	0.774	<.001	6	view →
LUSC	DFS	Median	II,III,IV	0.235	0.711	.006	6	view →
SCLC	DFS	Median	All	0.768	0.214	.043	2	view →
SKCM	DFS	Median	All	0.953	0.717	.028	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

DISC1–OV (OS)

Open the OV breakdown →