DISC1

Across TCGA patient cohorts, DISC1 RNA expression is significantly associated with the protein abundance of many other proteins, with 13,885 significant associations in total. HNSC shows the largest number of these associations.

The most reproducible DISC1-associated proteins across cancer lineages are DISC1_S97, SDC4, and MTERF3. Each is linked with DISC1 in more than 5 cancer types. Because this analysis shows association rather than direction, both DISC1-to-partner and partner-to-DISC1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, DISC1 versus DISC1_S97 in UCEC, with a Pearson correlation of 0.56.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (DISC1→partner) and Y-score (partner→DISC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	DISC1_S97 →	+0.856	+1.026	<.001	<.001	3	6
OV	SDC4 →	-0.559	-0.722	.003	<.001	3	6
PDAC	MTERF3 →	-0.560	-0.549	.001	<.001	3	5
BRCA	YME1L1 →	-0.384	-0.351	<.001	.003	3	5
CCRCC	MAP2_T1649 →	+1.013	+0.360	<.001	<.001	3	4
LSCC	PGAP1 →	+0.601	+0.518	.001	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 13,885 associations by consensus.

DISC1 vs DISC1_S97 — UCEC

Explore this scatter interactively →