DISC1

Across TCGA patient cohorts, DISC1 protein abundance is significantly associated with the RNA expression of many other genes, with 2,224 significant associations in total. CCRCC shows the largest number of these associations.

The most reproducible DISC1-associated genes across cancer lineages are EPAS1, FOXO1, and HMGB1P39. Each is linked with DISC1 in more than 2 cancer types. Because this analysis shows association rather than direction, both DISC1-to-partner and partner-to-DISC1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, DISC1 versus EPAS1 in CCRCC, with a Pearson correlation of 0.44.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DISC1→partner) and Y-score (partner→DISC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	EPAS1 →	+0.810	+0.539	.007	.001	3	3
CCRCC	FOXO1 →	+0.804	+0.505	<.001	.001	3	3
LUAD	HMGB1P39 →	+0.596	+0.322	<.001	<.001	3	3
UCEC	AURKA →	-1.409	-0.631	.002	.006	3	3
CCRCC	NFKBIA →	+0.454	+0.280	.006	.005	3	2
LUAD	RGCC →	+0.869	+0.374	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,224 associations by consensus.

DISC1 vs EPAS1 — CCRCC

Explore this scatter interactively →