DISC1

Across TCGA patient cohorts, DISC1 mutation is significantly associated with the total protein of many other genes, with 47 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DISC1-associated genes across cancer lineages are c-Jun_pS73, MEK1, and PKC-b-II_pS660. Each is linked with DISC1 in more than 3 cancer types. Because this analysis shows association rather than direction, both DISC1-to-partner and partner-to-DISC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, c-Jun_pS73 grouped by DISC1-low versus DISC1-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DISC1→partner) and Y-score (partner→DISC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	c-Jun_pS73 →	-0.171	-3.000	.030	.035	3	4
UCEC	MEK1 →	+0.291	+2.415	.007	.002	3	3
UCEC	PKC-b-II_pS660 →	-0.182	-1.184	.027	.022	3	3
UCEC	Cyclin-B1 →	+0.520	+1.847	.001	.007	3	3
UCEC	Cyclin-E2 →	+0.125	+1.378	.012	.008	3	3
UCEC	INPP4B →	-0.237	-1.662	.014	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 47 associations by consensus.

c-Jun_pS73 by DISC1 expression — SKCM

Explore this box plot interactively →