DISC1

Across TCGA cell cohorts, DISC1 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,780 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible DISC1-associated GO terms across cancer lineages are Positive regulation of telomere maintenance via telomerase, Regulation of telomere maintenance, and Regulation of focal adhesion assembly. Each is linked with DISC1 in more than 10 cancer types. Because this analysis shows association rather than direction, both DISC1-to-partner and partner-to-DISC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of telomere maintenance via telomerase grouped by DISC1-low versus DISC1-high in BREAST.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (DISC1→partner) and Y-score (partner→DISC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	Positive regulation of telomere maintenance via telomerase →	+0.110	+0.682	<.001	.001	3	11
OESOPHAGUS	Regulation of telomere maintenance →	+0.054	+0.505	.003	.001	3	11
OESOPHAGUS	Regulation of focal adhesion assembly →	+0.145	+0.620	<.001	.002	3	10
OESOPHAGUS	Regulation of cell-substrate junction assembly →	+0.145	+0.620	<.001	.002	3	10
OESOPHAGUS	Regulation of myoblast fusion →	+0.126	+0.402	<.001	.009	2	10
BREAST	Regulation of telomerase RNA localization to Cajal body →	+0.129	+0.668	<.001	.002	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,780 associations by consensus.

Positive regulation of telomere maintenance via telomerase by DISC1 expression — BREAST

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