DISC1

Across TCGA cell cohorts, DISC1 mutation is significantly associated with the RNA expression of many other genes, with 195 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible DISC1-associated genes across cancer lineages are RNASE8, LYZL6, and CBY1. Each is linked with DISC1 in more than 1 cancer types. Because this analysis shows association rather than direction, both DISC1-to-partner and partner-to-DISC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNASE8 grouped by DISC1-low versus DISC1-high in SOFT_TISSUE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DISC1→partner) and Y-score (partner→DISC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	RNASE8 →	+0.039	+5.369	<.001	.004	3	1
SOFT_TISSUE	LYZL6 →	+0.019	+5.369	<.001	.004	3	1
LARGE_INTESTINE	CBY1 →	+0.671	+3.330	<.001	.002	3	1
LARGE_INTESTINE	IFT27 →	+0.762	+2.451	.005	.009	3	1
LARGE_INTESTINE	AHSA1 →	+0.431	+3.386	.002	.001	3	1
LARGE_INTESTINE	PIGL →	+0.677	+3.169	.005	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 195 associations by consensus.

RNASE8 by DISC1 expression — SOFT_TISSUE

Explore this box plot interactively →