DIS3L2

Across TCGA pan-cancer cohorts, DIS3L2 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated DIS3L2 data layer compared with 25 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher DIS3L2 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated DIS3L2 expression acts as an unfavorable survival marker, although some lineages such as CCRCC show a favorable association.

CCRCC, LUAD, and GBM are the cancer types where DIS3L2 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Quartile	All	0.982	0.390	.018	14	view →
LUAD	OS	Tertile	III,IV	0.543	0.826	.012	8	view →
GBM	OS	Tertile	All	0.246	0.601	.042	2	view →
HNSC	OS	Median	All	0.957	1.000	.017	2	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

DIS3L2–CCRCC (DFS)

Open the CCRCC breakdown →