DIS3L2

Across TCGA patient cohorts, DIS3L2 RNA expression is significantly associated with the protein abundance of many other proteins, with 13,968 significant associations in total. GBM shows the largest number of these associations.

The most reproducible DIS3L2-associated proteins across cancer lineages are SF3B3, HDAC2, and ILKAP. Each is linked with DIS3L2 in more than 5 cancer types. Because this analysis shows association rather than direction, both DIS3L2-to-partner and partner-to-DIS3L2 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, DIS3L2 versus SF3B3 in LSCC, with a Pearson correlation of 0.41.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (DIS3L2→partner) and Y-score (partner→DIS3L2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	SF3B3 →	+0.234	+0.474	<.001	<.001	3	6
GBM	HDAC2 →	+0.374	+0.288	<.001	.002	3	6
LSCC	ILKAP →	+0.401	+0.573	<.001	<.001	3	6
LSCC	ADNP →	+0.437	+0.468	<.001	<.001	3	6
LSCC	GTF3C2 →	+0.297	+0.420	<.001	<.001	3	5
HNSC	HNRNPA3 →	+0.235	+0.466	.003	.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 13,968 associations by consensus.

DIS3L2 vs SF3B3 — LSCC

Explore this scatter interactively →