DIS3L2

Across TCGA patient cohorts, DIS3L2 mutation is significantly associated with the total protein of many other genes, with 37 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DIS3L2-associated genes across cancer lineages are Notch1, eIF4E, and Annexin-1. Each is linked with DIS3L2 in more than 2 cancer types. Because this analysis shows association rather than direction, both DIS3L2-to-partner and partner-to-DIS3L2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by DIS3L2-low versus DIS3L2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DIS3L2→partner) and Y-score (partner→DIS3L2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.206	+3.115	<.001	<.001	3	3
UCEC	eIF4E →	+0.204	+3.100	.003	<.001	3	3
UCEC	Annexin-1 →	+0.569	+2.926	.001	<.001	3	2
UCEC	eIF4G →	+0.278	+2.222	.006	.009	3	2
UCEC	FoxM1 →	+0.193	+1.652	.023	.006	3	2
UCEC	Ku80 →	+0.293	+1.951	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 37 associations by consensus.

Notch1 by DIS3L2 expression — UCEC

Explore this box plot interactively →