DIS3L2

Across TCGA cell cohorts, DIS3L2 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,562 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible DIS3L2-associated GO terms across cancer lineages are Chromosome separation, Mitotic sister chromatid separation, and Polyuridylation-dependent mRNA catabolic process. Each is linked with DIS3L2 in more than 18 cancer types. Because this analysis shows association rather than direction, both DIS3L2-to-partner and partner-to-DIS3L2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Chromosome separation grouped by DIS3L2-low versus DIS3L2-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (DIS3L2→partner) and Y-score (partner→DIS3L2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Chromosome separation →	+0.164	+0.639	<.001	<.001	3	19
SKIN	Mitotic sister chromatid separation →	+0.170	+0.691	.002	<.001	3	18
LUNG_NSCLC_LUSC	Polyuridylation-dependent mRNA catabolic process →	+0.131	+1.064	<.001	<.001	3	16
UPPER_AERODIGESTIVE_TRACT	Flagellated sperm motility →	-0.113	-0.608	<.001	<.001	3	15
BONE	Negative regulation of translational initiation →	+0.133	+0.627	<.001	<.001	3	15
UPPER_AERODIGESTIVE_TRACT	Sperm motility →	-0.113	-0.608	<.001	<.001	3	15

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,562 associations by consensus.

Chromosome separation by DIS3L2 expression — BONE

Explore this box plot interactively →