DIS3

Across TCGA pan-cancer cohorts, DIS3 Mutation is linked to patient survival in 11 of 34 cancer types, making it a survival-associated DIS3 data layer compared with 22 for mass-spec protein and 4 for mass-spec protein.

The strongest signal is observed in acute myeloid leukemia (LAML), where higher DIS3 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated DIS3 expression acts as an unfavorable survival marker, although some lineages such as UCEC and BLCA show a favorable association.

LAML, KICH, and UCS are the cancer types where DIS3 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LAML	DFS	Median	All	0.069	0.576	<.001	18	view →
KICH	DFS	Median	All	0.102	0.848	.004	13	view →
UCS	OS	Median	All	0.185	0.686	.034	6	view →
GBM	DFS	Median	All	0.052	0.257	.002	6	view →
SARC	DFS	Median	All	0.081	0.632	<.001	6	view →
HNSC	OS	Median	III,IV	0.153	0.656	.014	6	view →
UCEC	OS	Median	All	0.966	0.658	.032	6	view →
PRAD	DFS	Median	All	0.201	0.775	.015	6	view →
LUAD	OS	Median	III,IV	0.163	0.659	.035	6	view →
SKCM	OS	Median	IV	0.247	0.752	.004	6	view →
BLCA	OS	Median	II,III,IV	1.000	0.701	.034	4	view →

Pink = unfavorable, green = favorable. Showing the 11 strongest of 11 lineages.

DIS3–LAML (DFS)

Open the LAML breakdown →