DIS3

Across TCGA patient cohorts, DIS3 RNA expression is significantly associated with the protein abundance of many other proteins, with 11,942 significant associations in total. PDAC shows the largest number of these associations.

The most reproducible DIS3-associated proteins across cancer lineages are RBM26, CUL4A, and STK24. Each is linked with DIS3 in more than 6 cancer types. Because this analysis shows association rather than direction, both DIS3-to-partner and partner-to-DIS3 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, DIS3 versus RBM26 in OV, with a Pearson correlation of 0.54.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (DIS3→partner) and Y-score (partner→DIS3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	RBM26 →	+0.375	+0.735	<.001	<.001	3	7
HNSC	CUL4A →	+0.364	+0.647	<.001	<.001	3	6
OV	STK24 →	+0.430	+0.401	<.001	.006	3	6
PDAC	SUGT1 →	+0.299	+0.453	<.001	<.001	3	6
CCRCC	ARHGEF7 →	+0.270	+0.359	<.001	<.001	3	5
OV	MTMR6 →	+0.362	+0.473	<.001	.006	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 11,942 associations by consensus.

DIS3 vs RBM26 — OV

Explore this scatter interactively →