DIS3

Across TCGA patient cohorts, DIS3 protein abundance is significantly associated with the RNA expression of many other genes, with 12,638 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible DIS3-associated genes across cancer lineages are PCID2, BORA, and RBM26. Each is linked with DIS3 in more than 7 cancer types. Because this analysis shows association rather than direction, both DIS3-to-partner and partner-to-DIS3 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, DIS3 versus PCID2 in OV, with a Pearson correlation of 0.49.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DIS3→partner) and Y-score (partner→DIS3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	PCID2 →	+0.626	+0.366	<.001	<.001	3	8
OV	BORA →	+0.718	+0.245	.002	.005	3	8
LSCC	RBM26 →	+0.700	+0.402	<.001	<.001	3	8
LSCC	IPO5 →	+0.755	+0.328	<.001	<.001	3	8
GBM	UPF3A →	+0.505	+0.254	<.001	<.001	3	7
BRCA	GTF2F2 →	+0.485	+0.220	<.001	.002	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 12,638 associations by consensus.

DIS3 vs PCID2 — OV

Explore this scatter interactively →