DIS3

Across TCGA patient cohorts, DIS3 mutation is significantly associated with the RNA expression of many other genes, with 2,228 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible DIS3-associated genes across cancer lineages are RNU6-793P, DHRS2, and GALNT18. Each is linked with DIS3 in more than 2 cancer types. Because this analysis shows association rather than direction, both DIS3-to-partner and partner-to-DIS3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-793P grouped by DIS3-low versus DIS3-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DIS3→partner) and Y-score (partner→DIS3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	RNU6-793P →	+0.671	+5.366	<.001	.005	3	3
UCEC	DHRS2 →	+1.427	+1.857	<.001	<.001	3	2
UCEC	GALNT18 →	-0.511	-1.836	.005	.001	3	2
UCEC	MRPL18 →	+0.364	+1.868	<.001	<.001	3	2
UCEC	GLE1 →	+0.363	+2.362	.001	<.001	3	2
UCEC	NAA35 →	+0.406	+2.272	.002	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,228 associations by consensus.

RNU6-793P by DIS3 expression — STAD

Explore this box plot interactively →