DIS3

Across TCGA cell cohorts, DIS3 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,085 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible DIS3-associated GO terms across cancer lineages are Ribosomal protein import into nucleus, CUT catabolic process, and Sister chromatid biorientation. Each is linked with DIS3 in more than 15 cancer types. Because this analysis shows association rather than direction, both DIS3-to-partner and partner-to-DIS3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Ribosomal protein import into nucleus grouped by DIS3-low versus DIS3-high in BREAST.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (DIS3→partner) and Y-score (partner→DIS3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	Ribosomal protein import into nucleus →	+0.127	+0.730	.001	.002	3	16
LUNG_NSCLC_LUAD	CUT catabolic process →	+0.142	+0.871	<.001	<.001	3	16
LUNG_SCLC	Sister chromatid biorientation →	+0.180	+1.018	<.001	<.001	3	13
LARGE_INTESTINE	Positive regulation of mRNA catabolic process →	+0.060	+0.836	<.001	<.001	3	13
URINARY_TRACT	Protein desumoylation →	+0.086	+1.021	<.001	<.001	3	13
LUNG_SCLC	Protein localization to kinetochore →	+0.131	+1.061	<.001	<.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,085 associations by consensus.

Ribosomal protein import into nucleus by DIS3 expression — BREAST

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