DIS3

Across TCGA cell cohorts, DIS3 mutation is significantly associated with the RNA expression of many other genes, with 35 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible DIS3-associated genes across cancer lineages are BPIFA1, GCM2, and PDILT. Each is linked with DIS3 in more than 1 cancer types. Because this analysis shows association rather than direction, both DIS3-to-partner and partner-to-DIS3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, BPIFA1 grouped by DIS3-low versus DIS3-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (DIS3→partner) and Y-score (partner→DIS3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	BPIFA1 →	+0.152	+2.688	<.001	.008	3	2
BLOOD_Myeloma	GCM2 →	+0.010	+2.781	.002	.006	3	1
BLOOD_Myeloma	PDILT →	+0.004	+2.754	<.001	.008	3	1
BLOOD_Myeloma	KRTAP6-1 →	+0.062	+2.754	.001	.008	3	1
BLOOD_Myeloma	GPR141 →	+0.456	+2.643	.002	.009	3	1
BLOOD_Myeloma	ANGPTL5 →	+0.026	+3.415	.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 35 associations by consensus.

BPIFA1 by DIS3 expression — LARGE_INTESTINE

Explore this box plot interactively →