DIRC3

Across TCGA pan-cancer cohorts, DIRC3 RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated DIRC3 data layer.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where higher DIRC3 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated DIRC3 expression acts as an unfavorable survival marker, although some lineages such as UCS and ESCA show a favorable association.

LIHC, UCS, and UCEC are the cancer types where DIRC3 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LIHC	OS	Tertile	All	0.657	0.832	<.001	69	view →
UCS	OS	Tertile	III,IV	0.652	0.247	<.001	64	view →
UCEC	DFS	Median	All	0.787	0.885	<.001	58	view →
KIRP	DFS	Median	All	0.355	0.788	<.001	54	view →
LGG	OS	Median	All	0.713	0.903	<.001	50	view →
ESCA	OS	Median	All	0.634	0.478	.003	48	view →
LAML	DFS	Median	All	0.326	0.586	<.001	42	view →
SKCM	OS	Quartile	All	0.401	0.252	.002	38	view →
CESC	OS	Quartile	IV	0.808	0.105	.003	36	view →
HNSC	DFS	Median	III,IV	0.485	0.724	.002	35	view →
BRCA	OS	Tertile	II,III,IV	0.488	0.649	.010	20	view →
LUSC	OS	Median	All	0.788	0.732	.010	12	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

DIRC3–LIHC (OS)

Open the LIHC breakdown →