DIRC1

Across TCGA pan-cancer cohorts, DIRC1 Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated DIRC1 data layer compared with 20 for mass-spec protein.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where higher DIRC1 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated DIRC1 expression acts as an unfavorable survival marker.

BLCA, LUSC, and SARC are the cancer types where DIRC1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BLCA	OS	Median	All	0.149	0.710	<.001	36	view →
LUSC	OS	Median	All	0.223	0.777	<.001	18	view →
SARC	DFS	Median	All	0.037	0.632	<.001	12	view →
LUAD	OS	Median	All	0.323	0.834	.046	3	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

DIRC1–BLCA (OS)

Open the BLCA breakdown →